An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans
In the nematode C.elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides.Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptides.DAF-2B arises via alternative splicing and retain