AN ALTERNATIVELY SPLICED, NON-SIGNALING INSULIN RECEPTOR MODULATES INSULIN SENSITIVITY VIA INSULIN PEPTIDE SEQUESTRATION IN C. ELEGANS

An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

In the nematode C.elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides.Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptides.DAF-2B arises via alternative splicing and retain

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Pulmonary talcosis in the setting of cosmetic talcum powder use

Pulmonary talcosis synovex one grass is a rare pneumoconiosis that is difficult to diagnose and may progress to debilitating lung disease.Four types of talcosis are described in literature: talc-silicosis and talc-asbestosis secondary to inhalation in industry workers and talc-emboli in intravenous drug users that self-inject talc-containing oral t

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